The liver is one of the most important organs, being involved in a number of vital processes. It is the largest solid organ in the body, containing millions of liver cells called hepatocytes.
Hepatitis C is a liver disease caused by the RNA virus, which is transmitted primarily through blood, during transfusions, drug use or unprotected sex. There are 6 types of hepatitis C virus identified so far, the most common being genotype 1. Three percent of people in the world are infected in this moment with Hepatitis C. This virus is hiding in the live, causing cirrhosis and cancer. This condition is the main cause of liver transplant, and for this reason, the liver as an organ is needed in many countries.
A new class of drugs is fighting against Hepatitis C (HCV) without “disturbing” the immune system. A group of researchers have developed an investigation device which determines the forms of hepatitis, refractory to treatment, which have developed resistance to some specific drugs. More than 170 million people are carriers of viral hepatitis C who later develop severe liver disease.
The new medical technology against Hepatitis C named CoFIM and works to identify “cellular cofactors” and the action mechanism. “Cellular cofactors” are proteins of host cells which were attacked by viruses.
Cyclophilin A (CyPA) is a cellular cofactor determinant of infection with hepatitis C and a favorite target for new anti-HCV action, which hold in their composition cyclosporine A (CsA).
Researchers have discovered not only the dependence HVC of cofactor Cyclophilin A and susceptibility to drugs which contain cyclosporine A, but also regulators on the cellular level, that are like “tiny RNA libraries’ collections of molecules that have the ability to suppress the proceedings of genes.
The HCV induces mutation of the virus Hepatitis C in vitro, in the absence of regular replicative, received from one certain molecular cofactor. CoFIM follows changes occurring after being administrated the drugs on the basis of cyclosporine that inhibit the key cofactor.
Every year about four million people are infected with this virus and the most common source of infection are unsterilized needles and also 15% other cases represented by sexually transmitted HCV and about 10% are caused by infected blood transfusions.




